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Which system coordinates and controls the overall operation of the human body?

  1. Circulatory system

  2. Nervous system

  3. Endocrine system

  4. Musculoskeletal system

The correct answer is: Nervous system

The nervous system is responsible for coordinating and controlling the overall operation of the human body. The circulatory system is responsible for transporting nutrients and oxygen throughout the body, while the endocrine system is responsible for regulating hormones. The musculoskeletal system is responsible for movement and support of the body. While all of these systems are important for human functioning, the nervous system is specifically responsible for coordinating and controlling all of the body's functions. Therefore, option B is the correct answer.